Regulated Spatial Distribution of Cyclooxygenases and Lipoxygenases in Crohn's Ulcer

Endocannabinoid Oxygenation by Cyclooxygenases, Lipoxygenases, and Cytochromes P450: Cross-Talk between the Eicosanoid and Endocannabinoid Signaling Pathways

Gene expression of 5-, 12-, and 15-lipoxygenases and leukotriene receptors along the rat nephron.

The arachidonate signaling pathways comprise prostanoids formed by cyclooxygenases, EETs, and HETEs formed by cytochrome P-450 (CYP) enzymes and HETEs and leukotrienes generated by lipoxygenases. Whereas the intrarenal localization of cyclooxygenases and of some CYP enzymes along the nephron has already been determined, the localization of lipoxygenases and leukotriene-forming enzymes together ...

A paradigm of lipoxygenase and cyclooxygenase metabolism: Focusing new insights and positive biofeedback in the treatment and chemoprevention of pancreatic cancer

In human body, we have two essential fatty acids such as linoleic acid and arachidonic acid which are playing an important role in the development and progression of pancreatic cancer. Both of these fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Extensive scientific studies show that abnormal expression and activities of both cyclooxygenases and lipoxygenases a...

Proinflammatory and Immunoregulatory Roles of Eicosanoids in T Cells

Eicosanoids are inflammatory mediators primarily generated by hydrolysis of membrane phospholipids by phospholipase A2 to ω-3 and ω-6 C20 fatty acids that next are converted to leukotrienes (LTs), prostaglandins (PGs), prostacyclins (PCs), and thromboxanes (TXAs). The rate-limiting and tightly regulated lipoxygenases control synthesis of LTs while the equally well-controlled cyclooxygenases 1 a...

Inhibition of lipoxygenases and cyclooxygenases by linoleyl hydroxamic acid: comparative in vitro studies.

In this first comparative in vitro study, linoleyl hydroxamic acid (LHA), a simple and stable derivative of linoleic acid, was tested as an inhibitor of several enzymes involved in arachidonic acid metabolism in mammals. The tested enzymes were human recombinant 5-lipoxygenase (h5-LO), porcine leukocyte 12-LO, rabbit reticulocyte 15-LO, ovine cyclooxygenases 1/2 (COX1/COX2), and human microsoma...